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The inflammation is another mechanism triggered by FRD in rat intestine, as suggested by an increment in the intestinal protein expression of nuclear factor (NF)-B and interleukin (IL)-6

Moreover, 4F was shown to inhibit in vitro replication of SARS-COV-2 (Kelesidis et al., 2021)

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Nuclear factor kappaB (NF-kB) signaling pathway plays a role in COVID-19 progression and selenium is a NF-kB inhibitor